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Old September 25, 2003, 07:12   #1
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Toxoplasmosis is the name of a syndrome caused by a particularly clever protozoan parasite toxoplasma gondii that although it can affect many mammals including humans, it can only sexually reproduce in the guts of cats. However, as part of its life cycle it grows as tiny, infertile cyst cultures in the brains and nerve tissues of other mammals, producing degenerative damage. Now, for a long time it was assumed that the degenerative damage was non-adaptive, but recent findings have shown that evolutionary pressures have produced strains of toxoplasma gondii that cause infected rats to lose their fear of cats. Similarly, it causes infected cats to kill these rats and eat their brains. A convenient method for transmitting the cysts from the rat brains into the cat's guts, where they reproduce and their spores are then excreted in cat poo, to be picked up inadvertently by passing mammals, producing either direct infection, or infection through undercooked beef (using cattle as a secondary vector).

For the immunocompetent majority, it is believed to be harmless, and symptoms are usually diagnosed as a viral infection, including chills, fever, headaches and fatigue. Following these early signs, the parasite proceeds to hide from the immune system in muscle and nerve tissue causing a latent form of toxoplasmosis.
There's also the particularly nasty possibility that the parasite passes through the placenta to infect a developing human foetus. This produces mental retardation, eye disease, and hearing loss, and afflicts several tens of thousands of people annually.

People have speculated for a while on what if any behavioural effects a latent toxoplasma gondii infection would have on humans.

The manipulation hypothesis states a parasite may alter host behaviour for its own benefit, often by enhancing its transmission rate through the food chain. This paper reviews studies on the potential impact of one parasite, Toxoplasma gondii, on host behaviour, both on rodents, where altered responses may be proposed to benefit the parasite, and humans, where altered responses may arise as a side-effect of infection with no current adaptive significance.

It's pretty well established that such infections decrease reaction times, produce lethargy, and lead to an increase in traffic accidents. The authors of an Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study have a great deal to say on this topic.

The parasite Toxoplasma gondii infects 30–60% of humans worldwide. Latent toxoplasmosis, i.e., the life-long presence of Toxoplasma cysts in neural and muscular tissues, leads to prolongation of reaction times in infected subjects ... subjects with latent toxoplasmosis have significantly increased risk of traffic accidents than the non-infected subjects. Because of its high prevalence and therefore extremely high attributable mortality, latent toxoplasmosis, the mildest form of T. gondii infection, might in fact represent a serious and highly underestimated economic and public health problem.

But there's a couple of possibly nastier outcomes from the widespread, cat-induced slow plague spreading through humanity...

For nearly 30 years Dr Fuller Torrey, director of the Stanley Medical Research Institute, Maryland, USA, and his colleague Dr Robert Yolken, a Neurovirologist Professor at John Hopkins University, Baltimore, USA, have maintained that an infectious disease is the cause of schizophrenia and manic-depressive illnesses ... Early evidence for the consideration of cats as the prime cause of the disease has shown that in areas of the world where cats are common such as Germany, Ireland and Scandinavia, there is a comparatively high prevalence of schizophrenia compared to areas where they are less common, such as Papua New Guinea ... It has also been reported that individuals with first-onset schizophrenia have increased levels of antibodies to toxoplasmosis in their blood, and were readily exposed to cats during their childhood.

But perhaps the most contentious suggestion of mass-scale toxoplasma gondii human behaviour modification is the "slut theory", first hinted at in Flegr's classic page turner of operationalised psychology Changes in the personality profile of young women with latent toxoplasmosis.

Two years later, in 1999, Flegr carried out more tests, this time on a range of young women, and intended to discover exactly what the changes were. He concluded that there was a definite difference in personality profiles between the infected and uninfected individuals that he’d tested). Surprisingly, he concluded that those with latent toxoplasmosis had higher intelligence and lower guilt proneness.

the personality profiles of infected subjects differ from those of uninfected controls. These results, however, were obtained on non-standard populations (biologists or former acute toxoplasmosis patients). Here we studied the personality profiles of 191 young women tested for anti-Toxoplasma immunity during gravidity. The results showed that the differences between Toxoplasma-negative and Toxoplasma-positive subjects exits also in this sample of healthy women.

the personality profiles of women with latent toxoplasmosis differ in certain factors from those of women without toxoplasmosis. Toxoplasma-positive women have higher intelligence, guilt proneness (are more apprehensive, self-reproaching, insecure), possibly also higher ergic tension and radicalism.
The ability of toxoplasma gondii to infect a broad spectrum of mammal hosts is a very recent evolutionary development, stemming from a single lucky gene shuffling from two parental strains less than 10 KYear ago. And the adoption of the domestic cat is very recent, dating back around 10 KYear in isolated portions of the Middle East while the earliest domestic cats were seen in Europe around 400 CE. It seems that the toxoplasma gondii infection in humans is still working through its permutations.

Now Flegr's latest research (Correlation of duration of latent Toxoplasma gondii infection with personality changes in women and Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii) contends that latent toxoplasmosis effects in humans are gendered: female bodies feel a different range of physiological and psychological effects than male bodies. Something to do with dopamine sensitivities... Anyway, males tend to become withdrawn and aggressive, while females become energised, reckless, and giddy. The actual study, of course, is rather dry, so maybe it's better to let the tabloids speak for themselves...

Britain's estimated nine million domestic cats are being blamed by scientists for infecting up to half the population with a parasite that can alter people’s personalities. The figures emerge from studies into toxoplasma gondii, a parasite carried by almost all the UK's feline population and maybe elsewhere in the world. They show that half of Britain's human population carry the parasite in their brains, and that infected people may undergo slow but crucial changes in their behaviour. Infected men, suggests one new study, tend to become more aggressive, scruffy, antisocial and are less attractive. Women, on the other hand, appear to exhibit the 'sex kitten' effect, becoming less trustworthy, more desirable, fun-loving and possibly more promiscuous.

It can make women behave like "sex kittens" and men like "alley cats," the London Daily Mirror said. Women who are affected spend more on clothes and are consistently rated as more attractive, an international study has shown. They are more confident and less willing to conform to accepted moral standards. Researcher Jaroslav Flegr said: "We found they were more easy-going, more warmhearted, had more friends and cared more about how they looked. "However, they were also less trustworthy and had more relationships with men," he said. In contrast, infected men become more anti-social, suspicious and jealous, more aggressive, scruffier and less attractive to women.

Famous moggy owners include stunning Hollywood star Demi Moore, 40, who is having a passionate affair with Ashton Kutcher, 25, and pop babe Dannii Minogue, though there is no suggestion they have the bug.

Uh-huh. This is what happens when you encourage evolutionary biologists to blather on to journalists...
The apparent influence of T. gondii on the personality of human males was unexpected and pronounced. The nature of the shift in human personality following Toxoplasma infection can hardly be considered desirable. It might seem anecdotal that in a group of 29 Toxoplasma negative professors from our experimental set there are 10 present or past decision-makers (heads of department, vicedeans and deans) while among 14 Toxoplasma positive professors there is only a single head of department.
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Old September 25, 2003, 07:13   #2
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The return of the spam translator?
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Old September 25, 2003, 08:13   #3
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Old September 25, 2003, 08:26   #4
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Quote:
Originally posted by Ecthelion
The return of the spam translator?
nope, it's been in a few 'news'papers over here
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Old September 25, 2003, 08:54   #5
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Old September 25, 2003, 08:58   #6
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yes, though I havn't seen one in a while!
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Old September 25, 2003, 08:59   #7
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So can you give me a brief summary of what that ... thing up there is all about?
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Old September 25, 2003, 09:07   #8
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Women who own cats are horny sex predators ;O)
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Old September 25, 2003, 09:09   #9
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What about women who are cats, such as catwoman?
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Old September 25, 2003, 09:09   #10
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Translation: Handle cat crap carefully or you'll turn into a scruffy alley cat yourself.
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Old September 25, 2003, 09:10   #11
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And candy!! I said let them eat cake and candy!!
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Old September 25, 2003, 09:11   #12
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Old September 25, 2003, 09:13   #13
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That's Marie Antoinette's last attempt to evade decapitation.
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Old September 25, 2003, 09:24   #14
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This is a very disappointing thread.
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Old September 25, 2003, 10:10   #15
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Yeah. It even exceeds the "cheerleaders gone wild" proportions.
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Old September 25, 2003, 10:14   #16
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it sorta sucks

I like cats, and this is not good for cat owners

(better for women than men though)

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Old September 25, 2003, 10:14   #17
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Old September 25, 2003, 10:14   #18
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i've never understood why certain feminine body parts were named after cats.

this, i suppose, doesn't really clarify things much.

oh, and can i have a link to an article? a cite?
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Old September 25, 2003, 12:07   #19
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Whch female body part is named Garfield?
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Old September 25, 2003, 12:10   #20
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Yup, I heard about this yesterday and was looking for an article to post on it but couldn't.

Toxoplasm also can cause Schizophrenia, Depression, and birth defects in unborn children (obviously)...

This is why pregnant women shouldn't change litter boxes, and all cat owners are CRAZY...!@

oh wait, I have a cat...!

who said that?

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Old September 25, 2003, 12:37   #21
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In train spotting didn't the guy's friend die from Toxoplasmosis?
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Old September 25, 2003, 12:45   #22
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Yep.

Why isn't this a picture thread? :doitnow:
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Old September 25, 2003, 12:49   #23
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Did he? All they knew was he had his face in a ditch if vomit. The flat might have smelled after kitten because it wasn't looked after for days.
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Old September 25, 2003, 12:55   #24
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The idea that parasites can change the behavior of their hosts is actually a very interesting one. I remember seeing a film which the show Nova did on the habits of brackish water snails in San Elijo lagoon here in San Diego. I know the subject doesn't sound exciting but it really was an interesting piece of science.

It seems that when a local parasite infects the snails the snails start to behave very strangely. They abandon their shells, their skin turns a bright yellow and orange striped color, and instead of hiding under rocks or staying hidden in foliage the snails actually climb out of the water onto water grass blades where they are easy prey for shore birds. The end result is that the birds eat the infected snails and then the parasite gets spread as the birds poop in other nearby bodies of water.
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Old September 25, 2003, 12:59   #25
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Thus, after a long chain of eat and get eaten, resulting in the parasites infesting the human race and starting WW3.
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Old September 25, 2003, 23:07   #26
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Hmmmm, this sounds like the beginning of an endosymbiotic relationship, like when a few yeas ago some ameobae were infected with bacteria, and now that population of ameobae needs the bacteria to live. These things are very common in nature. Our mitochondria are actually endosybiotic bacteria, decendants of a Typhus-like parisite of protozoans 2 billion years ago, that eventually became peaceful residents helping thier anaerobic host to deal with the increase of oxygen levels, and then the host used the symbiont as a way to fuel itself aerobically.

Finnally a thread where I can spew my biological knoledge.
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Old September 26, 2003, 04:34   #27
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Can you cure this parasitic disease?
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Old September 26, 2003, 04:55   #28
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If it's a bacterial infection then wouldn't anti-biotics kill it? If it's a virus then you (we?) are just screwed.
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Old September 26, 2003, 04:57   #29
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According to "De Telegraaf", a newspaper here, it's uncurable. Then again, I don't believe anything De Telegraaf says.
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Old September 26, 2003, 13:00   #30
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exterminate
we must go on a world wide rampage to exterminate all cats.
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